Open Accessβ‐Blockers and Vascular Hemodynamics in Patients With Peripheral Arterial Disease
Author(s) -
Schlager Oliver,
Gajdosova Kovacicova Ludmila,
Senn Oliver,
AmannVesti Beatrice,
Wilkinson Ian B.,
Jacomella Vincenzo,
Husmann Marc
Publication year - 2016
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12854
Subject(s) - medicine , cardiology , blood pressure , peripheral , pulse pressure , hemodynamics , aortic pressure , vascular disease , heart rate
Aortic augmentation index ( AI x) is a marker of central aortic pressure burden and is modulated by antihypertensive drugs. In patients with peripheral arterial disease ( PAD ) undergoing antihypertensive treatment, aortic pressures parameters, heart rate–adjusted augmentation index ( AI x75), and unadjusted AI x were determined. The (aortic) systolic and diastolic blood pressure did not differ between PAD patients who were taking β‐blockers (n=61) and those who were not taking β‐blockers (n=80). In patients taking β‐blockers, augmentation pressure and pulse pressure were higher than in patients who did not take β‐blockers (augmentation pressure, P =.02; pulse pressure, P =.005). AI x75 was lower in PAD patients taking β‐blockers than in patients not taking β‐blockers ( P =.04), while the AI x did not differ between PAD patients taking and not taking β‐blockers. The present study demonstrates that β‐blockers potentially affect markers of vascular hemodynamics in patients with PAD . Because these markers are surrogates of cardiovascular risk, further studies are warranted to clarify the impact of selective β‐blocker treatment on clinical outcome in patients with PAD .