Open AccessEffect of Continuous Positive Airway Pressure on Blood Pressure Variability in Patients With Obstructive Sleep Apnea
Author(s) -
Pengo Martino F.,
Ratneswaran Culadeeban,
Berry Marc,
Kent Brian D.,
Kohler Malcolm,
Rossi Gian Paolo,
Steier Joerg
Publication year - 2016
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12845
Subject(s) - medicine , obstructive sleep apnea , continuous positive airway pressure , airway , blood pressure , sleep apnea , positive airway pressure , cardiology , sleep (system call) , apnea , anesthesia , computer science , operating system
Obstructive sleep apnea ( OSA ) is a common risk factor for cardiovascular disease. Continuous positive airway pressure ( CPAP ) improves OSA symptoms and blood pressure (BP) control. The effect of CPAP on BP variability ( BPV ) in patients with and without hypertension treated with autotitrating CPAP ( APAP ) for 2 weeks was studied. A total of 78 participants (76.9% men, 49% hypertensive, mean body mass index 36.2 [6.9] kg/m 2 , age 49.0 [12.9] years) underwent 2 weeks of APAP therapy. Office BP, BPV (standard deviation of three BP measurements), and pulse rate were measured before and after treatment. Systolic BPV (5.3±4.9 vs 4.2±3.4 mm Hg, P =.047) and pulse rate (78.0±14.5 vs 75.5±15.8 beats per minute, P =.032) decreased after treatment, particularly in hypertensive participants. Mask leak was independently associated with reduced changes in systolic BPV ( r =−0.237, P =.048). Short‐term APAP treatment reduced BPV and pulse rate, particularly in hypertensive patients with OSA .