Open AccessAnti‐Inflammatory Effects and Prediction of Blood Pressure Response by Baseline Inflammatory State in Catheter‐Based Renal Denervation
Author(s) -
Lang David,
Nahler Alexander,
Lambert Thomas,
Grund Michael,
Kammler Jürgen,
Kellermair Jörg,
Blessberger Hermann,
Kypta Alexander,
Steinwender Clemens,
Auer Johann
Publication year - 2016
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12844
Subject(s) - medicine , cystatin c , renal function , creatinine , denervation , blood pressure , white blood cell , urology , ambulatory blood pressure , inflammatory response , c reactive protein , endocrinology , gastroenterology , inflammation
This retrospective analysis aimed to examine off‐target effects on inflammatory and renal function parameters in n=78 subsequent patients treated with renal denervation ( RDN ) for resistant hypertension. Ambulatory and office blood pressure ( ABP / OBP ), serum creatinine, glomerular filtration rate ( GFR ), cystatin C, C‐reactive protein ( CRP ), interleukin‐6 ( IL ‐6), and white blood cell count ( WBC ) were assessed before, 6 and 12 months after RDN . ABP was significantly reduced by −8.2/−3.8 mm Hg ( P =.002/.021) at 1 year after RDN , while an initial OBP reduction was not sustained during follow‐up. IL ‐6 levels significantly decreased by −0.5 pg/mL ( P =.042) and by −1.7 pg/mL ( P <.001) at 6 and 12 months, baseline IL ‐6 levels possibly predicting ABP response to RDN ( r =−0.295; P =.020). Concurrently, leukocyte count was reduced by −0.5 × 10 3 /μL ( P =.017) and −0.8 × 10 3 /μL ( P <.001), respectively. Serum creatinine and GFR remained unchanged, but we observed a significant increase in cystatin C by 0.04 mg/L ( P =.026) and 0.14 mg/L ( P <.001) at 6 and 12 months after the intervention.