Open AccessSerum Beta‐Trace Protein as a Novel Predictor of Pregnancy‐Induced Hypertension
Author(s) -
Duan Bide,
Zhang Lei,
Ding Xiaoyan,
Li Ling,
Li Yuan,
Geng Hui,
Ma Yuyan
Publication year - 2016
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12801
Subject(s) - medicine , biomarker , pregnancy , receiver operating characteristic , serum concentration , endocrinology , obstetrics , gastroenterology , biochemistry , chemistry , genetics , biology
Beta‐trace protein ( BTP ) has emerged as a novel biomarker of cardiovascular risk. However, the level of circulating BTP in pregnancy‐induced hypertension ( PIH ) is still unknown. The aim of this study was to determine the concentration of serum BTP in healthy pregnant women and patients with PIH . No significant difference was found in the serum concentration of BTP in patients with a normal pregnancy. In contrast, serum BTP levels in women with PIH (n=46) were significantly higher than those in women with normal pregnancy (n=57). Receiver operating characteristic analysis revealed that using a serum BTP value of 321.3 ng/ mL as a cutoff produced a sensitivity of 91.3% and a specificity of 89.5%. Taken together, these findings suggest that a higher serum BTP concentration in PIH patients compared with those with normal pregnancy and serum BTP might be a novel biomarker in the diagnosis of PIH .