Open AccessAbnormalities of Anthropometric, Hemodynamic, and Autonomic Variables in Offspring of Hypertensive Parents
Author(s) -
Motta Josiane M.,
Lemos Tércio M.,
ConsolimColombo Fernanda M.,
Moyses Rosa M.A.,
Gusmão Marcelo A.N.,
Egan Brent M.,
Lopes Heno F.
Publication year - 2016
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12800
Subject(s) - medicine , offspring , anthropometry , blood pressure , hemodynamics , cardiology , body mass index , physiology , pregnancy , biology , genetics
Young adult offspring of hypertensive parents ( pHTN ⊕) are a good model for assessing abnormalities of anthropometric, cardiometabolic, and autonomic variables prior to clinical hypertension. The objectives of this study were to determine whether these variables and autonomic responses to oral carbohydrates were altered in offspring of pHTN ⊕. Two hundred consecutive patients, including 100 pHTN ⊕, were evaluated, with 29 patients, including 14 pHTN ⊕, given a 70‐gram carbohydrate load. The pHTN ⊕ group had higher blood pressure, pulse pressure, abdominal circumference ( AC ), weight, body mass index, and basal metabolic rate than offspring of normotensive parents ( pHTN ∅). At baseline, the low‐frequency ( LF , sympathetic) to high‐frequency ( HF , parasympathetic) ratio, assessed by spectral analysis of heart rate variability, was similar in both groups. After the carbohydrate load, the LF / HF ratio was greater in offspring of pHTN ⊕. pHTN ⊕ individuals have abnormalities of anthropometric and hemodynamic variables at baseline and autonomic responses to oral carbohydrates before developing hypertension.