Effect of Renal Sympathetic Denervation on Specific Micro RNA s as an Indicator of Reverse Remodeling Processes in Hypertensive Heart Disease | Zendy

Dörr Oliver | Zendy; Liebetrau Christoph | Zendy; Möllmann Helge | Zendy; Gaede Luise | Zendy; Troidl Christian | Zendy; Lankes Simone | Zendy; Guckel Denise | Zendy; Boeder Niklas | Zendy; Voss Sandra | Zendy; Bauer Timm | Zendy; Hamm Christian | Zendy; Nef Holger | Zendy

Open Access

Effect of Renal Sympathetic Denervation on Specific Micro RNA s as an Indicator of Reverse Remodeling Processes in Hypertensive Heart Disease

Author(s) -

Dörr Oliver,

Liebetrau Christoph,

Möllmann Helge,

Gaede Luise,

Troidl Christian,

Lankes Simone,

Guckel Denise,

Boeder Niklas,

Voss Sandra,

Bauer Timm,

Hamm Christian,

Nef Holger

Publication year - 2016

Publication title -

the journal of clinical hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.909

H-Index - 67

eISSN - 1751-7176

pISSN - 1524-6175

DOI - 10.1111/jch.12797

Subject(s) - medicine , denervation , disease , renal sympathetic denervation , sympathetic nervous system , sympathetic activity , cardiology , hypertensive heart disease , rna , endocrinology , heart failure , heart rate , blood pressure , resistant hypertension , biochemistry , chemistry , gene

A total of 90 consecutive patients undergoing renal sympathetic denervation (RSD) were included in this study. A significant reduction in office systolic blood pressure (SBP) of 21.1 mm Hg ( P <.001) was documented 6 months after RSD . At this time point, circulating concentrations of micro RNA (miR)‐133a were significantly increased (sevenfold; P <.001) compared with baseline values. Correlation analysis showed a significant relationship between baseline SBP values and SBP reduction ( P <.001) as well as between miR‐133a baseline levels and the increase in miR‐133a expression ( P <.001) after the 6‐month follow‐up. The effect of RSD on miR‐133a expression was significantly greater in patients at high risk for hypertensive heart disease . In addition to the effective blood pressure reduction in response to RSD , this study demonstrates an effect of RSD on miR reflecting cardiovascular reverse remodeling processes. Thus, these results provide information on a beneficial effect of RSD on cardiac recovery in patients at high risk for hypertensive heart disease .

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