Open AccessEffect of Renal Sympathetic Denervation on Specific Micro RNA s as an Indicator of Reverse Remodeling Processes in Hypertensive Heart Disease
Author(s) -
Dörr Oliver,
Liebetrau Christoph,
Möllmann Helge,
Gaede Luise,
Troidl Christian,
Lankes Simone,
Guckel Denise,
Boeder Niklas,
Voss Sandra,
Bauer Timm,
Hamm Christian,
Nef Holger
Publication year - 2016
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12797
Subject(s) - medicine , blood pressure , denervation , renal sympathetic denervation , cardiology , hypertensive heart disease , disease , endocrinology , heart failure , resistant hypertension
A total of 90 consecutive patients undergoing renal sympathetic denervation (RSD) were included in this study. A significant reduction in office systolic blood pressure (SBP) of 21.1 mm Hg ( P <.001) was documented 6 months after RSD . At this time point, circulating concentrations of micro RNA (miR)‐133a were significantly increased (sevenfold; P <.001) compared with baseline values. Correlation analysis showed a significant relationship between baseline SBP values and SBP reduction ( P <.001) as well as between miR‐133a baseline levels and the increase in miR‐133a expression ( P <.001) after the 6‐month follow‐up. The effect of RSD on miR‐133a expression was significantly greater in patients at high risk for hypertensive heart disease . In addition to the effective blood pressure reduction in response to RSD , this study demonstrates an effect of RSD on miR reflecting cardiovascular reverse remodeling processes. Thus, these results provide information on a beneficial effect of RSD on cardiac recovery in patients at high risk for hypertensive heart disease .