Effect of Renal Sympathetic Denervation on Specific Micro RNA s as an Indicator of Reverse Remodeling Processes in Hypertensive Heart Disease

A total of 90 consecutive patients undergoing renal sympathetic denervation (RSD) were included in this study. A significant reduction in office systolic blood pressure (SBP) of 21.1 mm Hg ( P <.001) was documented 6 months after RSD . At this time point, circulating concentrations of micro RNA (miR)‐133a were significantly increased (sevenfold; P <.001) compared with baseline values. Correlation analysis showed a significant relationship between baseline SBP values and SBP reduction ( P <.001) as well as between miR‐133a baseline levels and the increase in miR‐133a expression ( P <.001) after the 6‐month follow‐up. The effect of RSD on miR‐133a expression was significantly greater in patients at high risk for hypertensive heart disease . In addition to the effective blood pressure reduction in response to RSD , this study demonstrates an effect of RSD on miR reflecting cardiovascular reverse remodeling processes. Thus, these results provide information on a beneficial effect of RSD on cardiac recovery in patients at high risk for hypertensive heart disease .