Open AccessCardiorespiratory Fitness Suppresses Age‐Related Arterial Stiffening in Healthy Adults: A 2‐Year Longitudinal Observational Study
Author(s) -
Gando Yuko,
Murakami Haruka,
Kawakami Ryoko,
Yamamoto Kenta,
Kawano Hiroshi,
Tanaka Noriko,
Sawada Susumu S.,
Miyatake Nobuyuki,
Miyachi Motohiko
Publication year - 2016
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12753
Subject(s) - cardiorespiratory fitness , arterial stiffness , medicine , pulse wave velocity , cardiology , vo2 max , ankle , observational study , blood pressure , physical therapy , heart rate , surgery
Cardiorespiratory fitness is negatively associated with arterial stiffness, although it is unclear whether it is associated with prospective arterial stiffness changes. The authors examined cardiorespiratory fitness and arterial stiffness progression in a 2‐year follow‐up study of 470 healthy men and women aged 26 to 69 years. Peak oxygen uptake ( V ˙ O 2 peak) was measured at baseline using a graded cycle exercise test. Arterial stiffness was assessed using brachial‐ankle pulse wave velocity (ba PWV ) at baseline and after 2 years. Two‐year changes in ba PWV were significantly higher in patients in the lowestV ˙ O 2 peaktertile (28.8±7.6 cm/s) compared with those in the highestV ˙ O 2 peaktertile (−1.4±7.5 cm/s) ( P =.024) and were inversely correlated withV ˙ O 2 peak( r =−.112, P =.015). Stepwise multiple regression analysis revealed that age, glucose, ba PWV ,V ˙ O 2 peak, and sex were independent correlates of 2‐year changes in ba PWV , suggesting that higher cardiorespiratory fitness is associated with age‐related arterial stiffening suppression.