Open AccessArterial Stiffness, Central Pulsatile Hemodynamic Load, and Orthostatic Hypotension
Author(s) -
Liu Kai,
Wang Si,
Wan Shixi,
Zhou Yufei,
Pan Pei,
Wen Bo,
Zhang Xin,
Liao Hang,
Shi Di,
Shi Rufeng,
Chen Xiaoping,
Jangala Tulasiram
Publication year - 2016
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12726
Subject(s) - medicine , arterial stiffness , pulsatile flow , pulse wave velocity , hemodynamics , cardiology , confounding , blood pressure , orthostatic vital signs , logistic regression , pulse pressure , population , environmental health
The association between central pulsatile hemodynamic load, arterial stiffness, and orthostatic hypotension ( OH ) is unclear. The authors recruited 1099 participants from the community. Questionnaire, physical examination, and laboratory tests were performed. To assess the correlation between central pulsatile hemodynamic load, arterial stiffness, and OH , multiple logistic regression analysis was performed, and the discriminatory power was assessed by the area under the receiver operating curve . The prevalence of OH in this population was 5.6%. After adjusting for potential confounders, brachial‐ankle pulse wave velocity (Ba PWV ) was significantly and positively correlated with OH in both the hypertension and nonhypertension groups (all P< .05), while central systolic blood pressure ( CSBP ) was only significantly associated with OH in the hypertension subgroup. In addition, Ba PWV seemed to have a better discriminatory power than CSBP in both subgroups. Ba PWV appears to be a better indicator of OH than CSBP in routine clinical practice.