Open AccessAssociation Between Adiposity and Left Ventricular Mass in Children With Hypertension
Author(s) -
Brady Tammy M.,
Appel Lawrence J.,
Holmes Kathryn W.,
Fivush Barbara,
Miller Edgar R.
Publication year - 2016
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12717
Subject(s) - medicine , left ventricular hypertrophy , overweight , body mass index , cardiology , blood pressure , obesity , prospective cohort study , cohort , pulse pressure , mass index
Left ventricular hypertrophy ( LVH ) is prevalent among hypertensive children; however, blood pressure ( BP ) does not predict its presence. The authors conducted a 1‐year prospective cohort study to examine the hypothesis that obesity‐related risk factors are associated with left ventricular mass index ( LVMI ) in hypertensive children, and the association between adiposity and LVMI is mediated by BP ‐dependent and ‐independent pathways. A total of 49 hypertensive children were enrolled: 51% were overweight/obese and 41% had LVH at baseline. Children overweight/obese at baseline and follow‐up had a greater LVMI increase than those of healthy weight at each visit: mean change of 6.4 g/m 2.7 vs 0.95 g/m 2.7 . Baseline body mass index z score was independently associated with LVMI change (β=4.08, 1.54–6.61; P =.002). Only pulse pressure and serum aldosterone partially mediated this relationship. Hypertensive youth manifest multiple cardiovascular disease risk factors that worsen over time despite treatment. Of these, adiposity is most associated with LVH and increasing LVMI .