Open AccessPlasma Parathyroid Hormone Is Independently Related to Nocturnal Blood Pressure in Hypertensive Patients: The Styrian Hypertension Study
Author(s) -
Verheyen Nicolas D.,
Kienreich Katharina,
Gaksch Martin,
Ballegooijen Adriana J.,
Grübler Martin R.,
Hartaigh Briain Ó.,
Schmid Johannes,
FahrleitnerPammer Astrid,
KraigherKrainer Elisabeth,
Colantonio Caterina,
Belyavskiy Evgeny,
Treiber Gerlies,
Catena Cristiana,
Brussee Helmut,
Pieske Burkert,
März Winfried,
Tomaschitz Andreas,
Pilz Stefan
Publication year - 2016
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12710
Subject(s) - medicine , parathyroid hormone , blood pressure , nocturnal , hormone , ambulatory blood pressure , cardiology , endocrinology , calcium
High parathyroid hormone ( PTH ) has been linked with high blood pressure ( BP ), but the relationship with 24‐hour ambulatory blood pressure monitoring is largely unknown. The authors therefore analyzed cross‐sectional data of 292 hypertensive patients participating in the Styrian Hypertension Study (mean age, 61±11 years; 53% women). Median plasma PTH (interquartile range) determined after an overnight fast was 49 pg/ mL (39–61), mean daytime BP was 131/80±12/9 mm Hg, and mean nocturnal BP was 115/67±14/9 mm Hg. In multivariate regression analyses adjusted for BP and PTH ‐modifying parameters, PTH was significantly related to nocturnal systolic and diastolic BP (adjusted β‐coefficient 0.140 [ P =.03] and 0.175 [ P <.01], respectively). PTH was not correlated with daytime BP readings. These data suggest a direct interrelationship between PTH and nocturnal BP regulation. Whether lowering high PTH concentrations reduces the burden of high nocturnal BP remains to be shown in future studies.