Open AccessAmbulatory Blood Pressures in Hypertensive Patients Treated With One Antihypertensive Agent: Differences Among Drug Classes and Among Drugs Belonging to the Same Class
Author(s) -
Sierra Alejandro,
Gorostidi Manuel,
Banegas José R.,
Segura Julián,
Vinyoles Ernest,
Cruz Juan J.,
Ruilope Luis M.
Publication year - 2015
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12623
Subject(s) - medicine , ambulatory , bisoprolol , enalapril , atenolol , lisinopril , antihypertensive drug , blood pressure , amlodipine , drug , ambulatory blood pressure , pharmacology , drug class , confounding , angiotensin converting enzyme
The authors investigated the differences in office and ambulatory blood pressure ( BP ) among major antihypertensive drug classes and among frequently used drugs in each class in 22,617 patients treated with monotherapy from the Spanish ABPM Registry. Using thiazides as the reference group, patients treated with calcium channel blockers have significantly ( P <.01) elevated ambulatory BP and less ambulatory control after adjusting for confounders. Inside each class, no significant differences were observed among thiazides or angiotensin receptor blockers. Atenolol and bisoprolol among β‐blockers, amlodipine among calcium channel blockers, and lisinopril and enalapril among angiotensin‐converting enzyme inhibitors exhibited lower ambulatory BP and better control than other agents. Differences exist among antihypertensive drug classes and among different compounds in each class with respect to ambulatory BP control. This can help physicians choose among drug classes and among compounds in each class if BP reduction is the main objective of treatment.