Open AccessNocturnal Hypertension Correlates Better With Target Organ Damage in Patients With Chronic Kidney Disease than a Nondipping Pattern
Author(s) -
Wang Cheng,
Deng WenJie,
Gong WenYu,
Zhang Jun,
Zhang QunZi,
Ye Zeng Chun,
Lou Tanqi
Publication year - 2015
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12589
Subject(s) - medicine , dipper , kidney disease , nocturnal , cardiology , renal function , blood pressure , ambulatory blood pressure
Both nocturnal hypertension and nondipping pattern are associated with target organ damages ( TOD s); however, no data exist with respect to Chinese patients with chronic kidney disease ( CKD ). The authors recruited 1322 patients with CKD admitted to our hospital division and referred with data in this cross‐sectional study. Patients with nocturnal systolic hypertension had a lower estimated glomerular filtration rate ( eGFR ) and higher left ventricular mass index ( LVMI ) and carotid intima‐media thickness ( cIMT ) compared with patients with normal nocturnal systolic blood pressure ( SPB ; all, P <.001), while patients in the dipper and nondipper groups had similar levels of eGFR , LVMI , and cIMT when the patients had a similar nocturnal SBP . Factorial‐designed analysis of variance indicated that the main effect of nocturnal SBP was significant for all TOD differences (all, P <.001), but no significance existed with respect to the main effect of the dipper pattern and an interaction between the two factors (all, P >.05). Nocturnal systolic hypertension, rather than nondipping pattern, was an independent risk factor for TOD in CKD patients. Nocturnal hypertension, rather than a nondipping pattern, was better associated with TOD in CKD patients.