Open AccessArterial Stiffness and Peripheral and Central Blood Pressure in Patients With Sickle Cell Disease
Author(s) -
Pikilidou Maria,
Yavropoulou Maria,
Antoniou Maria,
Papakonstantinou Eleftherios,
Pantelidou Despoina,
Chalkia Panagiota,
Nilsson Peter,
Yovos John,
Zebekakis Pantelis
Publication year - 2015
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12572
Subject(s) - medicine , arterial stiffness , pulse wave velocity , blood pressure , body mass index , cardiology , population , pulse pressure , peripheral , diastole , sickle cell anemia , disease , environmental health
Blood pressure (BP) in patients with sickle cell disease (SCD) has been reported to be lower than in persons in the general population. Data on arterial stiffness, which is an important risk factor for the progression of BP, are inconclusive for this patient population. Forty‐five adult patients with SCD and 40 controls matched for sex, age, and body mass index were studied. Brachial systolic BP (SBP) and diastolic BP (DBP) were significantly lower in the patient group (SBP 115.1±13.8 mm Hg vs 121.9±11.3 mm Hg and DBP 68.5±8.0 mm Hg vs 80.6±9.1 mm Hg, P <.05, respectively). Augmentation index (AIx), however, was significantly higher in SCD patients compared with healthy controls (24.9±9.6 for patients vs 12.4±10.8 for controls, P <.001), while carotid femoral pulse wave velocity was comparable between the two groups. The study shows that mechanisms other than arterial elasticity are involved in the low BP phenotype of patients with SCD.