Open AccessAmbulatory Blood Pressure Monitoring–Derived Short‐Term Blood Pressure Variability in Primary Aldosteronism
Author(s) -
Grillo Andrea,
Bernardi Stella,
Rebellato Andrea,
Fabris Bruno,
Bardelli Moreno,
Burrello Jacopo,
Rabbia Franco,
Veglio Franco,
Fallo Francesco,
Carretta Renzo
Publication year - 2015
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12551
Subject(s) - primary aldosteronism , medicine , ambulatory blood pressure , blood pressure , aldosterone , ambulatory , cardiology , essential hypertension , body mass index , hyperaldosteronism , endocrinology
The aim of this study was to investigate the short‐term blood pressure ( BP ) variability ( BPV ) derived from ambulatory blood pressure monitoring ( ABPM ) in patients with primary aldosteronism ( PA ), either idiopathic hyperaldosteronism ( IHA ) or aldosterone‐producing adenoma ( APA ), in comparison with patients with essential hypertension ( EH ) and normotensive ( NT ) controls. Thirty patients with PA (16 with IHA and 14 with APA ), 30 patients with EH , and 30 NT controls, matched for sex, age, body mass index, and antihypertensive therapy, were studied. The standard deviation ( SD ) of 24‐hour, daytime, and nighttime BP ; 24‐hour weighted SD of BP ; and 24‐hour BP average real variability were not different between patients with PA and those with EH ( P =not significant). All BPV indices were higher in patients with PA , either IHA or APA subtypes, and patients with EH , compared with NT controls ( P <.001 to P <.05). ABPM ‐derived short‐term BPV is increased in patients with PA , and it may represent an additional cardiovascular risk factor in this disease. The role of aldosterone excess in BPV has to be clarified.