Open AccessRelationship Between Short‐Term Blood Pressure Variability and Subclinical Renal Damage in Essential Hypertensive Patients
Author(s) -
Mulè Giuseppe,
Calcaterra Ilenia,
Costanzo Miriam,
Geraci Giulio,
Guarino Laura,
Foraci Anna C.,
Vario Maria G.,
Cerasola Giovanni,
Cottone Santina
Publication year - 2015
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12534
Subject(s) - medicine , subclinical infection , blood pressure , cardiology , term (time) , essential hypertension , intensive care medicine , physics , quantum mechanics
The authors aimed to analyze the relationship between subclinical renal damage, defined as the presence of microalbuminuria or an estimated glomerular filtration rate (e GFR ) between 30 mL/min/1.73 m 2 and 60 mL/min/1.73 m 2 and short‐term blood pressure ( BP) variability, assessed as average real variability ( ARV ), weighted standard deviation ( SD ) of 24‐hour BP , and SD of daytime and nighttime BP . A total of 328 hypertensive patients underwent 24‐hour ambulatory BP monitoring, 24‐hour albumin excretion rate determination, and eGFR calculation using the Chronic Kidney Disease Epidemiology Collaboration equation. ARV of 24‐hour systolic BP ( SBP ) was significantly higher in patients with subclinical renal damage ( P =.001). This association held ( P =.04) after adjustment for potential confounders. In patients with microalbuminuria, ARV of 24‐hour SBP , weighted SD of 24‐hour SBP, and SD of daytime SBP were also independently and inversely related to eGFR . These results seem to suggest that in essential hypertension, short‐term BP variability is independently associated with early renal abnormalities.