Open AccessDo Obese Individuals With Hypertension Have More Difficult‐to‐Control Blood Pressure and End Organ Damage Than Their Nonobese Counterparts?
Author(s) -
Jesky Mark David,
Hayer Manvir Kaur,
Thomas Mark,
Dasgupta Indranil
Publication year - 2015
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12532
Subject(s) - medicine , overweight , body mass index , blood pressure , left ventricular hypertrophy , ambulatory blood pressure , obesity , diastole , end organ damage , cardiology , ambulatory , mass index , endocrinology
The authors assessed whether individuals with elevated body mass index ( BMI ) and hypertension had more difficult‐to‐control blood pressure ( BP) and more evidence of end organ damage using data collected prospectively over 11 years from a secondary care hypertension clinic. A total of 1114 individuals were divided by BMI criteria into normal (n=207), overweight (n=440), and obese (n=467). Mean daytime, nighttime, and 24‐hour systolic BP and diastolic BP were similar in all groups. There was less nocturnal dip in obese compared with overweight groups ( P =.025). Individuals with a normal BMI were taking fewer antihypertensive medications than those in the obese group ( P =.01). Individuals classified as obese had a higher left ventricular mass index than those with a normal BMI (female, P =.028; male, P <.001); this relationship remained after multivariate linear regression. Obese individuals with hypertension required more medication to achieve similar mean ambulatory BP values, had less nocturnal dip in BP , and had a higher prevalence of left ventricular hypertrophy. As such, obese patients are at potentially increased risk of cardiovascular events.