Open AccessAdiponectin Genotype, Blood Pressures, and Arterial Stiffness: The Cardiometabolic Risk in Chinese (CRC) Study
Author(s) -
Liang Jun,
Qiu Qinqin,
Gong Ying,
Liu Xuekui,
Dou Lianjun,
Zou Caiyan,
Wang Yu,
Qi Lu
Publication year - 2015
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12516
Subject(s) - arterial stiffness , medicine , adiponectin , waist , blood pressure , pulse wave velocity , body mass index , endocrinology , cardiology , body fat percentage , obesity , insulin resistance
The authors examined whether the adiponectin gene ( ADIPOQ ) variant was associated with blood pressure and arterial stiffness in Chinese adults. A genome‐wide association study of the adiponectin variant rs864265 in the ADIPOQ gene was genotyped in a total of 2364 participants. After adjustment for sex, age, body mass index ( BMI ), fasting glucose, and lipids, participants carrying the T allele of rs864265 showed a greater increase in carotid‐femoral pulse wave velocity (cf PWV ) and systolic blood pressure ( SBP ). Further adjustment for blood pressure did not appreciably change the association with cf PWV . The authors found significant interactions between rs864265 and BMI , waist circumference, body fat percentage, and SBP in relation to cf PWV (P for interaction = .035, .001, .003, .013, respectively). The T allele of rs864265 was associated with high blood pressure and arterial stiffness. BMI , body fat percentage, waist circumference, and SBP might modify the effects of genetic polymorphism on arterial stiffness.