Open AccessSleep Blood Pressure Self‐Measured at Home as a Novel Determinant of Organ Damage: Japan Morning Surge Home Blood Pressure (J‐ HOP ) Study
Author(s) -
Kario Kazuomi,
Hoshide Satoshi,
Haimoto Hajime,
Yamagiwa Kayo,
Uchiba Kiyoshi,
Nagasaka Shoichiro,
Yano Yuichiro,
Eguchi Kazuo,
Matsui Yoshio,
Shimizu Motohiro,
Ishikawa Joji,
Ishikawa Shizukiyo
Publication year - 2015
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12500
Subject(s) - medicine , morning , blood pressure , cardiology , evening , pulse wave velocity , end organ damage , ambulatory blood pressure , endocrinology , natriuretic peptide , heart failure , physics , astronomy
To study whether sleep blood pressure ( BP ) self‐measured at home is associated with organ damage, the authors analyzed the data of 2562 participants in the J‐ HOP study who self‐measured sleep BP using a home BP monitoring ( HBPM ) device, three times during sleep (2 am , 3 am , 4 am ), as well as the home morning and evening BP s. The mean sleep home systolic BP s (SBPs) were all correlated with urinary albumin/creatinine ratio ( UACR ), left ventricular mass index ( LVMI ), brachial‐ankle pulse wave velocity (ba PWV ), maximum carotid intima‐media thickness, and plasma N‐terminal pro‐hormone pro–brain‐type natriuretic peptide (NTproBNP) (all P <.001). After controlling for clinic SBP and home morning and evening SBP s, associations of home sleep SBP with UACR , LVMI , and ba PWV remained significant (all P <.008). Even in patients with home morning BP <135/85 mm Hg, 27% exhibited masked nocturnal hypertension with home sleep SBP ≥120 mm Hg and had higher UACR and NT pro BNP . Masked nocturnal hypertension, which is associated with advanced organ damage, remains unrecognized by conventional HBPM .