Open AccessAssociation Between Pulse Wave Velocity and a Marker of Renal Tubular Damage ( N ‐Acetyl‐β‐ D ‐Glucosaminidase) in Patients Without Diabetes
Author(s) -
Ouchi Motoshi,
Oba Kenzo,
Saigusa Taro,
Watanabe Kentaro,
Ohara Makoto,
Matsumura Noriaki,
Suzuki Tatsuya,
Anzai Naohiko,
Tsuruoka Shuichi,
Yasutake Masahiro
Publication year - 2015
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12492
Subject(s) - pulse wave velocity , medicine , arterial stiffness , renal function , creatinine , endocrinology , diabetes mellitus , kidney disease , blood pressure , urology , gastroenterology , cardiology
The authors assessed the association between the ratio of urinary activity of N‐acetyl‐β‐D‐glucosaminidase ( NAG ) to creatinine and the brachial‐ankle pulse wave velocity (ba PWV ) in patients without overt diabetes mellitus ( DM ). This was a cross‐sectional study of 233 patients who had an estimated glomerular filtration rate ( eGFR ) ≥30 mL/min/1.73 m 2 and no history of kidney disease. Patients were divided into two groups: high NAG group (>5.8 U/g creatinine) and low NAG group (≤5.8 U/g creatinine). Mean ba PWV s of the high NAG group were significantly higher than those of the low NAG group in both the eGFR ≥30 and <60 tertiles and the eGFR ≥60 and <90 tertiles. The ba PWV was positively correlated with NAG in all patients ( r =0.341, P <.001). Stepwise multivariate regression analysis showed that the ba PWV was significantly related with NAG , age, and systolic blood pressure. Elevated NAG is related to elevated arterial stiffness in patients without DM .