Open AccessPrognostic Significance of Visit‐to‐Visit Systolic Blood Pressure Variability: A Meta‐Analysis of 77,299 Patients
Author(s) -
Tai Chenhui,
Sun Yuxi,
Dai Neng,
Xu Dachun,
Chen Wei,
Wang Jiguang,
Protogerou Athanase,
Sloten Thomas T.,
Blacher Jacques,
Safar Michel E.,
Zhang Yi,
Xu Yawei
Publication year - 2015
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12484
Subject(s) - medicine , hazard ratio , confidence interval , blood pressure , stroke (engine) , cardiology , coefficient of variation , prospective cohort study , meta analysis , mechanical engineering , statistics , mathematics , engineering
In recent clinical investigations, visit‐to‐visit systolic blood pressure ( SBP ) variability was proven as a predictor of cardiovascular events and all‐cause mortality. However, inconsistent results exist in this association. A meta‐analysis of 13 prospective studies was conducted to evaluate the prognostic value of visit‐to‐visit SBP variability by different parameters in 77,299 patients with a mean follow‐up of 6.3 years. The pooled age‐ and mean SBP ‐adjusted hazard ratios ( HR s) for all‐cause mortality were 1.03 (95% confidence interval [ CI ], 1.02–1.04; P <.001) per 1‐mm Hg increase in SBP standard deviation ( SD ) and 1.04 (1.02–1.06, P <.001) per 1% in SBP coefficient of variation, and the corresponding values of cardiovascular mortality were 1.10 (1.02–1.17, P <.001) and 1.01 (0.99–1.03, P =.32), respectively. Moreover, a 1‐mm Hg increase in SD was significantly associated with stroke, with an HR of 1.02 (1.01–1.03, P <.001). Visit‐to‐visit SBP variability, independent of age and mean SBP , is a predictor of cardiovascular and all‐cause mortality and stroke.