Open AccessCerebral Blood Flow and Cognitive Function in Patients With Metabolic Syndrome: Effect of Antihypertensive Therapy
Author(s) -
Efimova Irina,
Efimova Natalya,
Lishmanov Yuri
Publication year - 2014
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12435
Subject(s) - cerebral blood flow , medicine , single photon emission computed tomography , metabolic syndrome , neuropsychology , cardiology , cognition , combination therapy , obesity , psychiatry
The aim of the study was to estimate regional cerebral blood flow ( rCBF ) and cognitive function in patients with metabolic syndrome (MetS) before and after antihypertensive combination therapy. The study included 24 patients with MetS (average age 52.4±1.6 years). All patients underwent brain single‐photon emission computed tomography with technetium‐99m hexamethylpropyleneamine oxime and comprehensive neuropsychological testing before and after 6‐month antihypertensive combination therapy. All patients with MetS showed lower rCBF values in all regions of the brain compared with the control group. Their parameters of attention, immediate visual memory, and mentation were lower by 25%, 22%, and 13% compared with the control group, respectively. Six‐month antihypertensive combination therapy increased cerebral perfusion and improved attention, mentation, and visual memory in MetS patients.