Open AccessAssociation of Hyperuricemia With Conventional Cardiovascular Risk Factors in Elderly Patients
Author(s) -
Marotta Teodoro,
Liccardo Maria,
Schettini Federico,
Verde Francesco,
Ferrara Aldo L.
Publication year - 2015
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12434
Subject(s) - medicine , hyperuricemia , uric acid , waist , triglyceride , body mass index , renal function , endocrinology , metabolic syndrome , obesity , cholesterol , cardiology
The relationship between serum uric acid (UA) and cardiovascular risk profile was investigated in 557 outpatients (415 women) aged 60 years and older. Patients were grouped according to a UA cutoff level of 5.5 mg/dL. Prevalence of obesity, hypertension, and impaired glucose metabolism was increased in women with higher UA, who had higher body mass index (37.7±6.9 vs 33.1±5.9 kg/m 2 , P <.001), waist circumference, and serum glucose and triglyceride concentrations than women with lower UA levels. Conversely, men with higher UA levels showed lower high‐density lipoprotein cholesterol and higher left ventricular mass than men with lower UA levels. Estimated glomerular filtration rate was reduced in patients with high UA levels of both sexes (65±17 vs 72±16 mL/min/1.73 m 2 , P <.001, for women; 70±16 vs 76±15 mL/min/1.73 m 2 , P <.03, for men). Grouping patients by sex‐specific median UA concentrations produced similar results. These data indicate that, even in the elderly, UA clusters in a sex‐specific fashion with features of metabolic syndrome and signs of target organ damage.