Open AccessRenal Sympathetic Denervation in Patients With Hypertension and Chronic Kidney Disease: Does Improvement in Renal Function Follow Blood Pressure Control?
Author(s) -
Kiuchi Márcio Galindo,
Chen Shaojie,
Andrea Bruno Rustum,
Kiuchi Tetsuaki,
Carreira Maria Angela Magalhães de Queiroz,
Graciano Miguel Luis,
Lugon Jocemir Ronaldo
Publication year - 2014
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12415
Subject(s) - medicine , renal function , urology , kidney disease , blood pressure , denervation , creatinine , renal sympathetic denervation , kidney , gastroenterology , resistant hypertension
Twenty‐seven patients with resistant hypertension and chronic kidney disease were treated by renal sympathetic denervation (RSD) and followed for 12 months. Patients were retrospectively divided into controlled and uncontrolled blood pressure (BP) groups. Increases in mean estimated glomerular filtration rate ( eGFR ) were found at months 1, 3, 6, and 12 in the controlled group ( P <.0001, for every time point). The mean change in eGFR after 12 months was 18.54±8.15 mL /min/1.73m 2 higher in the controlled group ( P =.0318). In patients in the controlled group with baseline eGFR <45 mL /min/1.73 m 2 , responders (with an increase in eGFR >6.2%) corresponded to 50% at 6 months and 83% at 12 months. In the patients with baseline eGFR ≥45 mL /min/1.73 m 2 , all patients were labeled as responders at months 6 and 12. Median albumin:creatinine ratio after 12 months was lower than baseline only in the controlled group ( P =.0003). Our results suggest that patients with this profile who reached BP control by RSD also experienced a significant improvement in renal function.