Open AccessLower Glomerular Filtration Rate Is Associated With Higher Systemic Vascular Resistance in Patients Without Prevalent Kidney Disease
Author(s) -
Vääräniemi Kati,
Koskela Jenni,
Tahvanainen Anna,
Tikkakoski Antti,
Wilenius Matias,
Kähönen Mika,
Kööbi Tiit,
Niemelä Onni,
Mustonen Jukka,
Pörsti Ilkka
Publication year - 2014
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12405
Subject(s) - medicine , renal function , vascular resistance , kidney disease , hemodynamics , blood pressure , cardiology , creatinine , cystatin c , impedance cardiography , kidney , pulse pressure , endocrinology , stroke volume , heart rate
The authors examined the association between estimated glomerular filtration rate ( eGFR ), calculated using the Chronic Kidney Disease Epidemiology Collaboration creatinine‐cystatin C equation, and hemodynamics in 556 normotensive or never‐treated hypertensive patients without kidney disease (mean age, 46 years). Hemodynamic variables were recorded using pulse wave analysis and whole‐body impedance cardiography. The mean e GFR was 98 mL/min/1.73 m 2 (range, 64–145 mL/min/1.73 m 2 and one third of the patients had values below 92, while none had proteinuria. In linear regression analyses adjusted for differences in age, weight:height ratio, low‐density lipoprotein cholesterol, and sex, significant associations were found between lower e GFR and higher systolic ( P =.001) and diastolic blood pressure ( P <.001) and higher systemic vascular resistance ( P =.001). There was no association between e GFR and cardiac output or extracellular volume. In the absence of clinical kidney disease, lower e GFR was associated with higher blood pressure and systemic vascular resistance. Therefore, early impairment in kidney function may be involved in the pathogenesis of essential hypertension.