Open AccessBrachial Pulse Pressure and Cardiovascular or All‐Cause Mortality in the General Population: A Meta‐Analysis of Prospective Observational Studies
Author(s) -
Zhao Leilei,
Song Yijuan,
Dong Pingshuan,
Li Zhijuan,
Yang Xuming,
Wang Shaoxin
Publication year - 2014
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12375
Subject(s) - medicine , observational study , pulse pressure , confidence interval , prospective cohort study , meta analysis , population , relative risk , blood pressure , cardiology , environmental health
This study aimed to quantitatively evaluate the predictive value of brachial pulse pressure and cardiovascular or all‐cause mortality in the general population based on prospective observational studies by conducting a meta‐analysis. Only prospective observational studies investigating baseline brachial pulse pressure and cardiovascular or all‐cause mortality risk were selected from PubMed and Embase databases until July 2013. Fourteen studies involving 510,456 participants were analyzed. Pooled risk ratio ( RR ) of cardiovascular and all‐cause mortality for the highest vs lowest brachial pulse pressure category was 1.80 (95% confidence interval [ CI ], 1.49–2.17) and 1.32 (95% CI, 1.23–1.41), respectively. Pooled RR of cardiovascular and all‐cause mortality per 10 mm Hg pulse pressure increment was 1.13 (95% CI, 1.10–1.17) and 1.09 (95% CI, 1.07–1.11), respectively. Wide brachial pulse pressure is associated with greater risk of cardiovascular and all‐cause mortality. However, more well‐designed studies specifically on age and sex are needed to further confirm these findings.