Open AccessThe Relationship Between Nocturnal Blood Pressure and Hemorrhagic Stroke in Chinese Hypertensive Patients
Author(s) -
Sun Jialan,
Yang Wanlin,
Zhu Yang,
Liu Xiaohong,
Wei Xin,
Wang Baisong,
Zhong Jiuchang,
Fu Yi
Publication year - 2014
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12369
Subject(s) - medicine , blood pressure , nocturnal , intracerebral hemorrhage , creatinine , stroke (engine) , cardiology , angiotensin converting enzyme , logistic regression , ambulatory blood pressure , dipper , anesthesia , mechanical engineering , subarachnoid hemorrhage , engineering
To study the relationship between nocturnal blood pressure ( BP ) variation and spontaneous intracerebral hemorrhage ( ICH ) among Chinese hypertensive patients and its clinical significance, the authors retrospectively screened 371 patients with primary hypertension (189 patients with ICH , 182 patients without ICH ) in S hanghai and analyzed their demographics, clinical information, nocturnal blood pressure variability and medication. Compared with the control group, the levels of blood glucose, triglycerides, and creatinine were significantly increased in the ICH group, along with a marked reduction in nocturnal BP drop ( P <.05). Multivariate logistic regression indicated that blood glucose, creatinine, and nocturnal mean arterial pressure were risk factors for ICH , and the magnitude of nocturnal BP drop was negatively related to the risk for ICH . There was no significant difference in the prevalence of reverse dippers between the large hematoma volume group and the small hematoma volume group (χ 2 =2.529, P =.112), nor among the patients taking angiotensin‐converting enzyme inhibitors, angiotensin receptor blockers, or calcium channel blockers (χ 2 =1.981, P =.371). Reverse dipping is associated with the risk for ICH , suggesting that appropriate antihypertensive drug and chronotherapy might be effective to normalize the rhythm of abnormal circadian variation in hypertensive patients.