Open AccessThe Effects of Catheter‐Based Radiofrequency Renal Denervation on Renal Function and Renal Artery Structure in Patients With Resistant Hypertension
Author(s) -
Zhang ZhiHui,
Yang Kan,
Jiang FengLin,
Zeng LiXiong,
Jiang WeiHong,
Wang XiaoYan
Publication year - 2014
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12367
Subject(s) - medicine , denervation , blood pressure , renal function , renal artery , renal sympathetic denervation , resistant hypertension , catheter , cardiology , urology , excretion , kidney , surgery
There are no clinical studies on the effects of catheter‐based radiofrequency renal denervation ( RDN ) on renal artery structure using 64‐detector computed tomography ( CT) . A total of 39 patients with resistant hypertension received RDN and 38 patients received drug treatment. Mean systolic pressure and diastolic pressure in the RDN group decreased after 1, 3, 6, and 12 months of procedure ( P <.05) and urinary protein level significantly decreased after 6 and 12 months ( P <.05). The diameter, length, and sectional area of the renal artery; number of cases of atherosclerosis; and plaque burden of 64‐detector CT renal arteriography did not change at 12 months of follow‐up ( P <.05), whereas the plaque burden increased significantly in the control group ( P <.05). RDN significantly and persistently reduced blood pressure and decreased urinary protein excretion rate in patients with resistant hypertension and did not exhibit any adverse effect on renal function and renal artery structure.