Open AccessRelationship Between Elevated Morning Blood Pressure Surge, Uric Acid, and Cardiovascular Outcomes in Hypertensive Patients
Author(s) -
Turak Osman,
Afsar Baris,
Ozcan Firat,
Canpolat Ugur,
Grbovic Enis,
Mendi Mehmet Ali,
Oksuz Fatih,
Siriopol Dimitrie,
Covic Adrian,
Caliskan Mustafa,
McFann Kim,
Johnson Richard J.,
Kanbay Mehmet
Publication year - 2014
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12359
Subject(s) - medicine , morning , blood pressure , cardiology , uric acid
Early morning blood pressure surge ( MBPS ) is a risk factor for cardiovascular events ( CVEs ), but the relationship with uric acid is not well understood. The authors aimed to determine the association between MBPS and increased uric acid and the effect of elevated MBPS and uric acid combination on CVEs . A total of 921 patients underwent 24‐hour ambulatory blood pressure monitoring and were followed for a median of 40 months. During this period, 103 (11.2%) CVEs occurred. There was a significant relationship between increasing quartiles of serum uric acid level and increasing values of MBPS ( P <.0001). Patients in the highest quartile stratified by elevated MBPS and serum uric acid level had a 3.55 odds of major CVE compared with patients in the lowest quartile. Serum uric acid is associated with MBPS and development of new CVEs .