Open AccessExercise‐Induced Pulse Wave Velocity Changes in Untreated Patients With Essential Hypertension: The Effect of an Angiotensin Receptor Antagonist
Author(s) -
Gkaliagkousi Eugenia,
Gavriilaki Eleni,
Nikolaidou Barbara,
Triantafyllou George,
Douma Stella
Publication year - 2014
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12340
Subject(s) - medicine , pulse wave velocity , arterial stiffness , blood pressure , cardiology , antagonist , essential hypertension , angiotensin ii , receptor antagonist , endocrinology , receptor
This study investigates arterial stiffness changes after acute exercise in young patients with untreated, recently diagnosed grade I essential hypertension ( UH ) compared with normotensive ( NT ) individuals and the effect of antihypertensive treatment on this phenomenon. Study 1 consisted of 25 UH and 15 NT patients . UH patients who received treatment were included in study 2 and were followed‐up after a 3‐month treatment period with an a ngiotensin II r eceptor b locker. Aortic p ulse w ave v elocity ( PWV ) was assessed at baseline, at maximal exercise, and at 10, 30, and 60 minutes later. In UH patients , PWV increased significantly at maximal exercise and 10 and 30 minutes of recovery, despite blood pressure fall to baseline levels. No significant PWV changes were observed in NT patients . Post‐treatment PWV levels were significantly decreased and similar to those of NT patients . Arterial stiffness is impaired following high‐intensity acute exercise even in the early stages of hypertension. Antihypertensive treatment ameliorates these effects.