Open AccessSerum Uric Acid and Hypertension in Adults: A Paradoxical Relationship in Type 1 Diabetes
Author(s) -
Bjornstad Petter,
Paul Wadwa R.,
Sirota Jeffrey C.,
SnellBergeon Janet K.,
McFann Kimberly,
Rewers Marian,
Rivard Christopher J.,
Jalal Diana,
Chonchol Michel B.,
Johnson Richard J.,
Maahs David M.
Publication year - 2014
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12305
Subject(s) - medicine , blood pressure , uric acid , diabetes mellitus , type 2 diabetes , endocrinology , cardiology
Adults with type 1 diabetes have lower serum uric acid levels compared with nondiabetic adults. Little is known about the relationship between serum uric acid and blood pressure in type 1 diabetes and whether it differs from the positive relationship found in nondiabetic adults. The authors assessed the cross‐sectional and longitudinal relationships over 6 years between serum uric acid and blood pressure in adults with (35±9 years [n=393]) and without (38±9 years [n=685]) type 1 diabetes in the Coronary Artery Calcification in Type 1 Diabetes study. In nondiabetic adults, serum uric acid was associated with systolic blood pressure in multivariable models adjusted for cardiovascular risk factors. In adults with type 1 diabetes, a negative association was observed between serum uric acid and systolic blood pressure after multivariable adjustments. A positive association was observed between serum uric acid and systolic blood pressure in nondiabetic adults. In contrast, an inverse relationship was demonstrated after multivariable adjustments in type 1 diabetes.