Open AccessRenal Sympathetic Denervation for Blood Pressure Control: A Review of the Current Evidence and Ongoing Studies
Author(s) -
Todoran Thomas M.,
Basile Jan N.,
Zile Michael R.
Publication year - 2014
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12285
Subject(s) - medicine , denervation , optimism , sympathetic nervous system , blood pressure , renal sympathetic denervation , intensive care medicine , disease , sympathectomy , cardiology , autonomic nervous system , clinical trial , resistant hypertension , heart rate , psychology , social psychology
Hypertensive heart disease is the leading cause of mortality and morbidity in the U nited S tates. Despite widespread availability of medical therapy, it remains a challenge to treat. Autonomic nervous system imbalance resulting in overactivity of the sympathetic nervous system is integral to the development of hypertension and ultimately the development of hypertensive heart disease. Although the results with renal sympathetic denervation so far have been encouraging, optimism has recently been tempered with the broadcast alert from M edtronic, the sponsor of S ymplicity HTN ‐3, that the trial did not meet its primary efficacy endpoint. The principal focus of this article is to review the developments in renal sympathetic denervation for the treatment of resistant hypertension.