Open AccessProgression of Aortic Pulse Wave Velocity in Patients With Chronic Kidney Disease
Author(s) -
Tholen Susanne,
Klofat Katharina,
Pan Cheng Rui,
Schmaderer Christoph,
Lutz Jens,
Heemann Uwe,
Baumann Marcus
Publication year - 2013
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12198
Subject(s) - medicine , pulse wave velocity , arterial stiffness , cardiology , kidney disease , renal function , blood pressure , pulse pressure , diabetes mellitus , cohort , endocrinology
Aortic p ulse w ave v elocity (a PWV ) is elevated in patients with chronic kidney disease (CKD) and predicts cardiovascular risk. However, the natural progression of arterial stiffness in these patients remains uncertain. Therefore, the main aim of this study was to investigate the development of a PWV and to identify potential factors associated with its progression. a PWV measurement was carried out in 70 CKD patients at baseline and after 12 months. Correlations to several variables, in particular annual glomerular filtration rate reduction and diabetes mellitus, were studied. In the cohort, a PWV significantly increased in 1 year by 1.1 m/s ( P <.01). Dividing the group into patients with stable and progressive a PWV , factors associated with accelerated progression were age, systolic blood pressure, and diabetes, whereas loss of renal function had no significant impact. The annual a PWV progression in CKD patients reached 1 m/s, which predicts an increased cardiovascular risk. Variables involved with progressive arterial stiffness need further evaluation.