Open AccessRelationship Between Inter‐Arm Difference in Systolic Blood Pressure and Arterial Stiffness in Community‐Dwelling Older Adults
Author(s) -
Canepa Marco,
Milaneschi Yuri,
Ameri Pietro,
AlGhatrif Majd,
Leoncini Giovanna,
Spallarossa Paolo,
Pontremoli Roberto,
Brunelli Claudio,
Strait James B.,
Lakatta Edward G.,
Ferrucci Luigi
Publication year - 2013
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12178
Subject(s) - medicine , arterial stiffness , pulse wave velocity , blood pressure , body mass index , cardiology , waist , odds ratio , confidence interval , diabetes mellitus , pulse pressure , endocrinology
A significant inter‐arm difference in systolic blood pressure ( IADSBP ) has recently been associated with worse cardiovascular outcomes. The authors hypothesized that part of this association is mediated by arterial stiffness, and examined the relationship between significant IADSBP and carotid‐femoral pulse wave velocity ( CF ‐ PWV ) in a sample from the Baltimore Longitudinal Study of Aging. Of 1045 participants, 50 (4.8%) had an IADSBP ≥10 mm Hg at baseline, and 629 had completed data from ≥2 visits (for a total of 1704 visits during 8 years). CF ‐ PWV was significantly higher in patients with an IADSBP ≥10 mm Hg (7.3±1.9 vs 8.2±2, P =.002). Compared with others, patients with IADSBP ≥10 mm Hg also had higher body mass index, waist circumference, and triglycerides; higher prevalence of diabetes; and lower high‐density lipoprotein (HDL) cholesterol ( P <.001 for all). A significant association with IADSBP ≥10 mm Hg was observed for CF ‐ PWV in both cross‐sectional ( odds ratio [OR] , 1.19; 95% confidence interval [ CI], 1.06–1.87; P =.01) and longitudinal (OR, 1.15; 95% CI, 1.03–1.29; P =.01) multivariate analyses. Female sex, Caucasian race, high body mass index (plus diabetes and low HDL cholesterol only cross‐sectionally) were other independent correlates of IADSBP ≥10 mm Hg. Significant IADSBP is associated with increased arterial stiffness in community‐dwelling older adults.