Open AccessIncreased Aortic Stiffness and Related Factors in Patients With Peripheral Arterial Disease
Author(s) -
Catalano Mariella,
Scandale Giovanni,
Carzaniga Gianni,
Cinquini Michela,
Minola Marzio,
Dimitrov Gabriel,
Carotta Maria
Publication year - 2013
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12167
Subject(s) - medicine , arterial stiffness , pulse wave velocity , cardiology , peripheral , arterial disease , applanation tonometry , blood pressure , ankle , pulse pressure , vascular disease , surgery
A number of conditions have been associated with functional changes of large arteries. The aim of this study was to evaluate the factors associated with aortic stiffness in patients with peripheral arterial disease (PAD). The authors studied 86 patients with PAD (ankle‐brachial pressure index [ABPI] ≤0.9) and 86 controls. Aortic stiffness was determined by pulse wave velocity ( aPWV ) using applanation tonometry. In PAD patients, aPWV was higher compared with controls (11±3 vs 9.8±1.8; P =.002). In multiple regression analysis, aPWV was independently associated with pulse pressure (β=0.05, P =.01) in the PAD patients and with age in the control group (β=0.08, P =.0005). The results of this study confirm an aPWV increase in patients with PAD and emphasize the association between blood pressure and aPWV . Further studies are necessary to assess whether higher aortic stiffening adds prognostic value to ABPI, which is the most powerful prognostic indicator in PAD.