Open AccessEfficacy/Safety of a Fixed‐Dose Amlodipine/Olmesartan Medoxomil–Based Treatment Regimen in Hypertensive Blacks and Non‐Blacks With Uncontrolled BP on Prior Antihypertensive Monotherapy
Author(s) -
Nesbitt Shawna,
Shojaee Ali,
Maa JenFue
Publication year - 2013
Publication title -
the journal of clinical hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 67
eISSN - 1751-7176
pISSN - 1524-6175
DOI - 10.1111/jch.12060
Subject(s) - medicine , olmesartan , hydrochlorothiazide , amlodipine , regimen , blood pressure , urology , dosing , fixed dose combination , valsartan
In this secondary analysis of a dose‐titration study of patients with hypertension uncontrolled on prior monotherapy, blacks (n=234) and non‐blacks (n=765) were switched to amlodipine ( AML )/olmesartan medoxomil ( OM ) 5/20 mg, with uptitration every 4 weeks to AML / OM 5/40 mg and then AML / OM 10/40 mg to achieve a seated cuff blood pressure ( S e BP ) of <120/70 mm H g. Hydrochlorothiazide 12.5 and 25 mg could be added if S e BP was ≥125/75 mm H g. The cumulative proportions of patients achieving systolic S e BP <140 mm H g (<130 mm H g if diabetic) at 12 weeks were 71.6% for blacks and 77.2% for non‐blacks. Mean S e BP change from baseline in blacks (mean baseline BP : 153.0/93.7 mm H g) ranged from −11.7/−6.1 mm H g for AML / OM 5/20 mg to −23.6/−12.9 mm Hg for AML / OM 10/40 mg +hydrochlorothiazide 25 mg (all P <.0001). Antihypertensive efficacy was maintained throughout the 24‐hour dosing interval. An AML / OM ‐based regimen was effective in blacks with hypertension uncontrolled on prior monotherapy.