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Renal denervation for the treatment of ventricular arrhythmias: A systematic review and meta‐analysis
Author(s) -
Prado Gabriela M.,
Mahfoud Felix,
Lopes Renato D.,
Moreira Dalmo A. R.,
Staico Rodolfo,
Damiani Lucas P.,
Ukena Christian,
Armaganijan Luciana V.
Publication year - 2021
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/jce.15004
Subject(s) - medicine , implantable cardioverter defibrillator , blood pressure , meta analysis , adverse effect , confidence interval , cardiology , renal function , denervation , anesthesia
Ventricular arrhythmias (VAs) are a major cause of morbidity and mortality in patients with heart disease. Recent studies evaluated the effect of renal denervation (RDN) on the occurrence of VAs. We conducted a systematic review and meta‐analysis to determine the efficacy and safety of this procedure. Methods and Results A systematic search of the literature was performed to identify studies that evaluated the use of RDN for the management of VAs. Primary outcomes were reduction in the number of VAs and implantable cardioverter–defibrillator (ICD) therapies. Secondary outcomes were changes in blood pressure and renal function. Ten studies (152 patients) were included in the meta‐analysis. RDN was associated with a reduction in the number of VAs, antitachycardia pacing, ICD shocks, and overall ICD therapies of 3.53 events/patient/month (95% confidence interval [CI] = −5.48 to −1.57), 2.86 events/patient/month (95% CI = −4.09 to −1.63), 2.04 events/patient/month (95% CI = −2.12 to −1.97), and 2.68 events/patient/month (95% CI = −3.58 to −1.78), respectively. Periprocedural adverse events occurred in 1.23% of patients and no significant changes were seen in blood pressure or renal function. Conclusions In patients with refractory VAs, RDN was associated with a reduction in the number of VAs and ICD therapies, and was shown to be a safe procedure.