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Predictors of permanent pacemaker insertion after TAVR: A systematic review and updated meta‐analysis
Author(s) -
Mahajan Sugandhi,
Gupta Rahul,
Malik Aaqib H.,
Mahajan Pranav,
Aedma Surya K.,
Aronow Wilbert S.,
Mehta Sanjay S.,
Lakkireddy Dhanunjaya R.
Publication year - 2021
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/jce.14986
Subject(s) - medicine , cardiology , valve replacement , odds ratio , left bundle branch block , meta analysis , aortic valve stenosis , stenosis , confidence interval , heart failure
Objectives The aim of this analysis was to evaluate the predictors associated with increased risk of permanent pacemaker implantation (PPMI) following transcatheter aortic valve replacement (TAVR). Background While TAVR has evolved as the standard of care for patients with severe aortic stenosis, conduction abnormalities leading to the need for PPMI is one of the most common postprocedural complications. Methods A systematic literature search was performed to identify relevant trials from inception to May 2020. Summary effects were calculated using a DerSimonian and Laird random‐effects model as odds ratio with 95% confidence intervals for all the clinical endpoints. Results Thirty‐seven observational studies with 71 455 patients were identified. The incidence of PPMI following TAVR was 22%. Risk was greater in men and increased with age. Patients with diabetes mellitus, presence of right bundle branch block, baseline atrioventricular conduction block, and left anterior fascicular block were noted to be at higher risk. Other significant predictors include the presence of high calcium volume in the area below the left coronary cusp and noncoronary cusp, use of self‐expandable valve over balloon‐expandable valve, depth of implant, valve size/annulus size, predilatation balloon valvuloplasty, and postimplant balloon dilation. Conclusion Fourteen factors were found to be associated with increased risk of PPMI after TAVR, suggesting early identification of high‐risk populations and targeting modifiable risk factors may aid in reducing the need for this post TAVR PPMI.