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Circulating intermediate monocytes and atrial structural remodeling associated with atrial fibrillation recurrence after catheter ablation
Author(s) -
Suehiro Hideya,
Kiuchi Kunihiko,
Fukuzawa Koji,
Yoshida Naofumi,
Takami Mitsuru,
Watanabe Yoshiaki,
Izawa Yu,
Akita Tomomi,
Takemoto Makoto,
Sakai Jun,
Nakamura Toshihiro,
Yatomi Atsusuke,
Takahara Hiroyuki,
Sonoda Yusuke,
Nakasone Kazutaka,
Yamamoto Kyoko,
Yamashita Tomoya,
Hirata Kenichi
Publication year - 2021
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/jce.14929
Subject(s) - medicine , catheter ablation , atrial fibrillation , cardiology , magnetic resonance imaging , ablation , receiver operating characteristic , cd14 , nuclear medicine , radiology , receptor
Background Inflammation, such as that associated with intermediate CD14 ++ CD16 + monocytes and atrial structural remodeling (SRM), may be important in the recurrence of atrial fibrillation (AF) after catheter ablation. However, the relationship between the intermediate CD14 ++ CD16 + monocytes, SRM, and AF recurrence is unclear. Methods Twenty‐four patients with AF were enrolled. The proportion of intermediate monocytes (PIM) was assessed before ablation by flow cytometry. As a surrogate marker of SRM, the volume ratio (VR) of signal intensity greater than 1 standard deviation on late‐gadolinium enhancement magnetic resonance imaging (LGE‐MRI) was calculated. We investigated whether PIM correlated with SRM on LGE‐MRI and determined the optimal cutoff value for predicting AF recurrence. Results Univariate analysis revealed positive correlations between PIM and BNP with SRM (PIM: r = .593, p = .002; BNP: r = .567, p = .004). Multivariable analysis revealed that PIM was independently associated with VR on LGE‐MRI ( β = .522; p = .033). The finding of an area under the receiver operating characteristic curve of 0.750 revealed that a VR ≥ 13.3% on LGE‐MRI as the optimal cutoff value to predict AF recurrence with 80% sensitivity and 71% specificity, which was associated with PIM ≥ 10.0%. Conclusion Intermediate monocytes were significantly positively correlated with SRM. PIM ≥ 10% was associated with a VR ≥ 13.3% on LGE‐MRI, which predicted AF recurrence after catheter ablation.