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Performance of a novel active fixation quadripolar left ventricular lead for cardiac resynchronization therapy: Attain Stability Quad Clinical Study results
Author(s) -
Jackson Kevin P.,
Faerestrand Svein,
Philippon Francois,
Yee Raymond,
Kong Melissa H.,
Kloppe Axel,
Bongiorni Maria Grazia,
Lee Scott F.,
Canby Robert C.,
Pouliot Erika,
Ginneken Mireille M. E.,
Crossley George H.
Publication year - 2020
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/jce.14439
Subject(s) - medicine , cardiac resynchronization therapy , coronary sinus , implant , lead (geology) , cardiology , fixation (population genetics) , surgery , heart failure , ejection fraction , population , environmental health , geomorphology , geology
The Medtronic Attain Stability Quad lead is a quadripolar left ventricular (LV) lead with an active fixation helix assembly designed to fixate the lead within the coronary sinus and pace nonapical regions of the LV. The primary objective of this study was to determine the safety and effectiveness of this novel active fixation quadripolar LV lead. Methods Patients with standard indications for cardiac resynchronization therapy (CRT) were enrolled. All patients were followed at 3 and 6 months post‐implant and every 6 months thereafter until study closure. Pacing capture thresholds (PCTs) were measured at implant and each follow‐up and adverse events (AEs) were recorded upon occurrence. Results Of the 440 patients who underwent implant procedures, placement of the Attain Stability Quad lead was successful in 426 (96.8%). LV lead‐related complications occurred in 10 patients (2.3%), including LV lead dislodgement in three patients (0.7%). The percentage of patients with at least one LV pacing vector with a PCT ≤2.5 V at a 6‐month follow‐up was 96.3%. The LV lead was successfully fixated to the prespecified pacing location in 97.4% of cases. Conclusions This large, multinational study of the Attain Stability Quad lead demonstrated a high rate of implant success with a low complication rate. The active fixation mechanism allowed precise placement of the pacing electrodes at the desired target region with good PCTs and a very low dislodgement rate.