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J Waves Are Associated With the Increased Occurrence of Life‐Threatening Ventricular Tachyarrhythmia in Patients With Nonischemic Cardiomyopathy
Author(s) -
NARUSE YOSHIHISA,
NOGAMI AKIHIKO,
SHINODA YASUTOSHI,
HANAKI YUICHI,
SHIRAI YASUHIRO,
KOWASE SHINYA,
KUROSAKI KENJI,
MACHINO TAKESHI,
KUROKI KENJI,
YAMASAKI HIRO,
IGARASHI MIYAKO,
SEKIGUCHI YUKIO,
AONUMA KAZUTAKA
Publication year - 2016
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/jce.13096
Subject(s) - medicine , cardiology , cardiomyopathy , heart failure
J Wave and VT/VF of Nonischemic Cardiomyopathy Introduction Recent studies showed that J waves were associated with higher incidence of ventricular tachyarrhythmia (VT/VF) in patients with idiopathic ventricular fibrillation (VF) and myocardial infarction. We sought to assess the association between J waves and VT/VF in patients with nonischemic cardiomyopathy (NICM). Methods and Results We retrospectively enrolled 109 patients (79 men; mean age, 60 ± 15 years) with NICM who underwent implantable cardioverter defibrillator (ICD) implantation. The primary endpoint of this study was the occurrence of appropriate device therapy due to sustained VT/VF. The J wave was electrocardiographically defined as an elevation of the terminal portion of the QRS complex of >0.1 mV in at least 2 contiguous inferior or lateral leads. Among the 109 patients, 37 (34%) experienced an episode of appropriate device therapy during a median follow‐up period of 25.9 (IQR 11.5–54.3) months. Kaplan‐Meier curves showed that the presence of J waves on the 12‐lead ECG obtained before device implantation was associated with an increased occurrence of appropriate device therapy (P < 0.001). Multivariate Cox proportional regression analysis revealed that the presence of J waves (HR 2.95; 95% CI 1.31–6.64; P = 0.009) was an independent predictor for the occurrence of appropriate device therapy. In the subgroup analysis of the patients with dilated or hypertrophic cardiomyopathy, J wave tended to increase the occurrence of appropriate device therapy (P = 0.056 and P = 0.092, respectively). Conclusions The presence of J waves was an independent predictor for the occurrence of appropriate device therapy in patients with NICM who underwent ICD implantation.