Premium
Rhodiola Inhibits Atrial Arrhythmogenesis in a Heart Failure Model
Author(s) -
LIU SHUENHSIN,
HSIAO YAWEN,
CHONG ERIC,
SINGHAL RAHUL,
FONG MANCAI,
TSAI YUNGNAN,
HSU CHIAOPO,
CHEN YAOCHANG,
CHEN YIJEN,
CHIOU CHUENWANG,
CHIANG SHUOJU,
CHANG SHIHLIN,
CHEN SHIHANN
Publication year - 2016
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/jce.13026
Subject(s) - rhodiola , medicine , ejection fraction , atrial fibrillation , cardiology , heart failure , placebo , enos , pharmacology , salidroside , nitric oxide , pathology , alternative medicine , nitric oxide synthase
Rhodiola Inhibits Atrial Arrhythmogenesis Introduction Rhodiola, a popular plant in Tibet, has been proven to decrease arrhythmia. The aim of this study was to elucidate the molecular mechanism and electrophysiological properties of rhodiola in the suppression of atrial fibrillation. Methods This study consisted of 3 groups as follows: Group 1: normal control rabbits (n = 5); Group 2: rabbits with heart failure (HF) created by coronary ligation and who received 2 weeks of water orally as a placebo (n = 5); and Group 3: rabbits with HF who received 2 weeks of a rhodiola 270 mg/kg/day treatment orally (n = 5). The monophasic action potential, histology, and real‐time polymerase chain reaction (RT‐PCR) analysis of ionic channels and PI3K/AKT/eNOS were examined. Results Compared with the HF group, attenuated atrial fibrosis (35.4 ± 17.4% vs. 16.9 ± 8.4%, P = 0.05) and improved left ventricular (LV) ejection fraction (51.6 ± 3.4% vs. 68.0 ± 0.5%, P = 0.001) were observed in the rhodiola group. The rhodiola group had a shorter ERP (85.3 ± 6.8 vs. 94.3 ± 1.2, P = 0.002), APD90 (89.3 ± 1.5 vs. 112.7 ± 0.7, P < 0.001) in the left atrium (LA), and decreased AF inducibility (0.90 ± 0.04 vs. 0.42 ± 0.04, P < 0.001) compared with the HF group. The mRNA expressions of Kv1.4, Kv1.5, Kv4.3, KvLQT1, Cav1.2, and SERCA2a in the HF LA were up‐regulated after rhodiola treatment. The rhodiola‐treated HF LA demonstrated higher mRNA expression of PI3K‐AKT compared with the HF group. Conclusions Rhodiola reversed LA electrical remodeling, attenuated atrial fibrosis and suppressed AF in rabbits with HF. The beneficial electrophysiological effect of rhodiola may be related to upregulation of Kv1.4, Kv1.5, Kv4.3, KvLQT1, Cav1.2, SERCA2a, and activation of PI3K/AKT signaling.