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Premature Ventricular Contraction Variability in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Author(s) -
CAMM CHRISTIAN F.,
TICHNELL CRYSTAL,
JAMES CYNTHIA A.,
MURRAY BRITTNEY,
PORTERFIELD FLORENCE,
TE RIELE ANNELINE S.J.M.,
TANDRI HARIKRISHNA,
CALKINS HUGH
Publication year - 2015
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1111/jce.12544
Subject(s) - medicine , arrhythmogenic right ventricular dysplasia , interquartile range , cardiomyopathy , cardiology , population , implantable cardioverter defibrillator , heart failure , environmental health
PVC Variability in ARVD/C Introduction Arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is an inherited cardiomyopathy, characterized by right ventricular dysfunction and ventricular arrhythmias. Premature ventricular contractions (PVCs) are an important measure in determining disease severity and constitute a minor criterion in the 2010 Task Force Criteria for the diagnosis of ARVD/C. Little information is available regarding the variability in PVCs. Methods and Results Patients (n = 40) from the Johns Hopkins ARVD/C registry, meeting diagnostic criteria were included. Single lead continuous 12‐lead electrocardiogram (ECG) monitors (Zio® Patches) were applied to monitor PVC counts. Detailed demographic, phenotypic, and structural information were obtained from registry data. ECG monitors were worn for a mean period of 159.3 hours (±39.3). Average 24‐hour PVC count in this population was 1,090.5 (interquartile range = 1,711). One‐way analysis of variance demonstrated statistically significant interday variance in mean hourly PVC counts in 76% of ARVD/C‐positive subjects (28/37, 3 cases excluded due to insufficient data). Eleven individuals (27.5%) had maximum 24‐hour PVC counts of >500 with a corresponding minimum 24‐hour PVC count of <500. The average 24‐hour PVC count for each patient was derived for each day recorded. The 24‐hour PVC count placed 89.6% of counts (223/249) on the correct side of the 500‐PVC count. Conclusion Statistically significant variation between 24‐hour PVC counts is present in the ARVD/C population. However, 24‐hour ECG monitoring was sufficient to identify 89.6% of 24‐hour periods to the correct grouping based on 2010 Task Force Criteria.