Premium
Weighted single‐step genome‐wide association study and pathway analyses for feed efficiency traits in Nellore cattle
Author(s) -
Brunes Ludmilla C.,
Baldi Fernando,
Lopes Fernando B.,
Lôbo Raysildo B.,
Espigolan Rafael,
Costa Marcos F. O.,
Stafuzza Nedenia B.,
Magnabosco Cláudio U.
Publication year - 2021
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/jbg.12496
Subject(s) - biology , residual feed intake , leptin , feed conversion ratio , gene , genome wide association study , genetic association , dry matter , genetics , endocrinology , medicine , zoology , body weight , genotype , obesity , single nucleotide polymorphism
The aim was to conduct a weighted single‐step genome‐wide association study to detect genomic regions and putative candidate genes related to residual feed intake, dry matter intake, feed efficiency (FE), feed conversion ratio, residual body weight gain, residual intake and weight gain in Nellore cattle. Several protein‐coding genes were identified within the genomic regions that explain more than 0.5% of the additive genetic variance for these traits. These genes were associated with insulin, leptin, glucose, protein and lipid metabolisms; energy balance; heat and oxidative stress; bile secretion; satiety; feed behaviour; salivation; digestion; and nutrient absorption. Enrichment analysis revealed functional pathways ( p ‐value < .05) such as neuropeptide signalling (GO:0007218), negative regulation of canonical Wingless/Int‐1 (Wnt) signalling (GO:0090090), bitter taste receptor activity (GO:0033038), neuropeptide hormone activity (GO:0005184), bile secretion (bta04976), taste transduction (bta0742) and glucagon signalling pathway (bta04922). The identification of these genes, pathways and their respective functions should contribute to a better understanding of the genetic and physiological mechanisms regulating Nellore FE‐related traits.