Premium
“ Arte et Labore ”—A Blackburn Rovers fan's legacy in human complex trait genetics
Author(s) -
Visscher Peter M.,
Wray Naomi R.,
Haley Chris S.
Publication year - 2019
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/jbg.12384
Subject(s) - linkage disequilibrium , genome wide association study , biology , quantitative genetics , population genetics , trait , evolutionary biology , population , genetic association , genetics , genealogy , allele , genetic variation , demography , sociology , computer science , single nucleotide polymorphism , history , genotype , haplotype , gene , programming language
Through his own research contributions on the modelling and genetic analysis of quantitative traits and through his former students and postdocs, Robin Thompson has indirectly left a major legacy in human genetics. In this short note, we highlight examples of the long‐lasting relevance and impact of Robin's work in human genetics. A lone early study of marker‐assisted selection developed many of the tools and approaches later exploited (often after reinvention) by the human genetics community in GWAS studies and for prediction. Furthermore, a particularly clear example of the pervasive impact of Robin's work is that REML has become the default method to estimate variance components and that genetic predictions exploiting linkage disequilibrium in the population are starting to become used in precision medicine applications.