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Novel harmful recessive haplotypes for reproductive traits in pigs
Author(s) -
Häggman J.,
Uimari P.
Publication year - 2017
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/jbg.12240
Subject(s) - haplotype , biology , genetics , breed , weaning , gene , lethal allele , population , genotype , zoology , demography , sociology
Summary Harmful recessive haplotypes for reproductive and fertility traits have previously been detected in cattle, but so far, no studies have been published for pigs. The aim of this study was to locate chromosomal regions with putative lethal haplotypes and estimate the effects of the identified haplotypes on reproductive traits in the Finnish Yorkshire pig breed. We used marker genotypes of 871 Finnish Yorkshire AI boars, genotyped with Illumina's Porcine SNP 60 BeadChip. The analysed traits were number of stillborn piglets in first ( NSB 1) and later ( NSB 2) parities, total number of piglets born in first and later parities and piglet mortality between birth and weaning in first and later parities. A haplotype was claimed as a putative lethal if it was common in the population, but no homozygous animals were found. We detected altogether 26 putative lethal haplotypes, but only one haplotype on chromosome 8 (position 107.0–113.3 Mb) was significantly associated with traits NSB 1 and NSB 2. Three possible candidate genes were found in this chromosomal region: MAD 2 LI , FGF 2 and ANXA 5. Further analysis is needed to confirm the role of these genes on pig reproductive performance.