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Genome‐wide study on intramuscular fat in Italian Large White pig breed using the Porcine SNP 60 BeadChip
Author(s) -
Davoli R.,
Luise D.,
Mingazzini V.,
Zambonelli P.,
Braglia S.,
Serra A.,
Russo V.
Publication year - 2016
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/jbg.12189
Subject(s) - intramuscular fat , biology , single nucleotide polymorphism , candidate gene , genetics , snp , quantitative trait locus , gene , large white , genome , breed , genetic association , genome wide association study , white (mutation) , genotype , zoology
Summary Genome‐wide association study results are presented for intramuscular fat in Italian Large White pig breed. A total of 886 individuals were genotyped with Porcine SNP 60 BeadChip. After quality control performed with plink software and in R environment, 49 208 markers remained for the association analysis. The genome‐wide association studies was conducted using linear mixed model implemented in Gen ABEL . We detected seven new SNP s of genes till now not found associated to intramuscular fat ( IMF ). Three markers map in a wide intergenic region rich of QTL linked to fat traits, one map 388 kb upstream the gene SDK 1 , one map inside PPP 3 CA gene, one inside SCPEP 1 gene and the last is not mapped in the porcine genome yet. Associations here presented indicate a moderate effect of these genes on IMF . In particular, PPP 3 CA , that is involved in the oxidative metabolism of skeletal muscle, could be considerated as an interesting candidate gene for IMF content in pigs. However, further studies are needed to clarify the role of these genes on the physiological processes involved in IMF regulation. These results may be useful to control this trait that is important in terms of nutritional, technological and organoleptic characteristics of fresh meat and processed products.