BSE ‐associated polymorphisms in the prion protein gene: an investigation | Zendy

Vernerova K. | Zendy; Tothova L. | Zendy; Mikova A. | Zendy; Vodrazka P. | Zendy; Simek B. | Zendy; Hanusova L. | Zendy; Citek J. | Zendy

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BSE ‐associated polymorphisms in the prion protein gene: an investigation

Author(s) -

Vernerova K.,

Tothova L.,

Mikova A.,

Vodrazka P.,

Simek B.,

Hanusova L.,

Citek J.

Publication year - 2014

Publication title -

journal of animal breeding and genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.689

H-Index - 51

eISSN - 1439-0388

pISSN - 0931-2668

DOI - 10.1111/jbg.12090

Subject(s) - indel , bovine spongiform encephalopathy , genotype , allele frequency , prnp , allele , biology , genetics , genotype frequency , polymorphism (computer science) , gene , prion protein , single nucleotide polymorphism , medicine , disease

Summary The aim of this study was to determine the frequency of the 12‐bp and 23‐bp indel polymorphisms in the prion protein gene ( PRNP ) in cattle and to investigate the association between these frequencies and the occurrence of bovine spongiform encephalopathy ( BSE ). There was no significant difference in the 12‐bp indel frequency between the BSE animals and control group. For the 23‐bp indel, the BSE animals had a significantly lower + + ( insins ) genotype frequency and + allele frequency compared with the control animals. The − − / − − genotype frequency in the BSE animals was not significantly higher when compared with the control animals. One − allele increased the risk of BSE by a factor of 1.55 (i.e. by 55%) for the 12‐bp indel and by a factor of 2.10 for the 23‐bp indel. When both indels are considered, one − allele increased the risk of BSE by a factor of 1.54.

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