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DECR 1 and ME 1 genotypes are associated with lipid composition traits in D uroc pigs
Author(s) -
Ramírez O.,
Quintanilla R.,
Varona L.,
Gallardo D.,
Díaz I.,
Pena R.N.,
Amills M.
Publication year - 2014
Publication title -
journal of animal breeding and genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 51
eISSN - 1439-0388
pISSN - 0931-2668
DOI - 10.1111/jbg.12035
Subject(s) - genotype , intramuscular fat , genetics , biology , allele , epistasis , linkage disequilibrium , missense mutation , population , gene , haplotype , mutation , zoology , medicine , environmental health
Summary Variation at the porcine DECR 1 and ME 1 genes has been associated with meat quality traits and backfat thickness in Landrace pigs, respectively. However, it has not been investigated yet whether DECR 1 and ME 1 genotypes influence lipid composition. With this aim, we have genotyped two missense DECR 1 substitutions (c.160G>C and c.437G>C) and one silent ME 1 (c.576C>T) polymorphism in 361 Duroc barrows distributed in five half‐sib families and phenotyped for serum lipid concentrations and intramuscular fat content and composition traits. At the whole‐population level, relevant associations, that is, with a posterior probability of the allele substitution effect to be over or below zero ( PPN 0) > 0.90, were observed between DECR 1 genotype and serum cholesterol (CHOL) ( PPN 0 = 0.932) and LDL concentrations ( PPN 0 = 0.945) at 190 days, as well as between ME 1 genotype and longissimus dorsi saturated fatty acid content ( PPN 0 = 0.924). At the within‐family level, we found relevant associations between DECR 1 and ME 1 genotypes and diverse lipid composition traits, but most of them were family‐specific. Discrepancies in allele substitution effects estimated in half‐sib families might be produced by many factors such as number of individuals, marker allele frequencies and informativeness in each family, unaccounted random genetic and environmental effects, epistasis and family‐specific differences in the linkage phase or amount of linkage disequilibrium between causal and marker mutations. This lack of consistency across families, combined with the fact that the ME 1 mutation is synonymous and that the two DECR 1 polymorphisms are conservative, suggests that the associations found are not causative.