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艾滋病病毒感染者的症状严重程度与治疗负担之间的关系
Author(s) -
Schreiner Nathanial,
Perazzo Joseph,
Digennaro Sarah,
Burant Christopher,
Daly Barbara,
Webel Allison
Publication year - 2020
Publication title -
journal of advanced nursing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 155
eISSN - 1365-2648
pISSN - 0309-2402
DOI - 10.1111/jan.14461
Subject(s) - medicine , psychological intervention , multivariate analysis , multivariate statistics , cross sectional study , depression (economics) , physical therapy , clinical psychology , psychiatry , statistics , mathematics , pathology , economics , macroeconomics
Abstract Aim To examine the association between symptoms severity and treatment burden in people living with HIV. Design Correlational, secondary analysis of data from participants diagnosed with HIV enrolled in a descriptive, cross‐sectional study examining physical activity patterns. Methods We analysed data from 103 men and women using self‐report data collected between March 2016 ‐ February 2017. Our primary statistical analyses consisted of explanatory multivariate modelling with individual PROMIS‐29 scores representing symptom severity and treatment burden measured using the Treatment Burden Questionnaire‐13. Results Greater symptom severity was associated with higher levels of cumulative treatment burden as well as higher levels of task‐specific medication and physical activity burden. Multivariate regression analyses revealed that fatigue was a risk factor of cumulative treatment burden as well as task‐specific medication and physical activity treatment burden. Effect sizes of multivariate models ranged from small (0.11) to medium (0.16). Additionally, post hoc analyses showed strong correlations between fatigue and other measured symptoms. Conclusion Findings support extant treatment burden literature, including the importance of addressing symptom severity in conjunction with treatment burden screening in the clinical setting. Results also suggest clinical interventions focused on the reduction of fatigue could reduce treatment burden in people living with HIV. Strong correlations between fatigue and other symptoms indicate the potential for reducing fatigue by addressing other highly clustered symptoms, such as depression. Impact People living with HIV exhibiting higher levels of fatigue are at high risk for treatment burden and poorer self‐management adherence. Clinicians should consider incorporating symptom and treatment burden assessments when developing, tailoring and modifying interventions to improve self‐management of HIV and other co‐morbid conditions.