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Impact of nursing interventions on adherence to treatment with antituberculosis drugs in children and young people: A nonrandomized controlled trial
Author(s) -
GuixComellas Eva Maria,
RozasQuesada Librada,
VelascoArnaiz Eneritz,
FerrésCanals Ariadna,
EstradaMasllorens Joan Maria,
ForceSanmartín Enriqueta,
NogueraJulian Antoni
Publication year - 2018
Publication title -
journal of advanced nursing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.948
H-Index - 155
eISSN - 1365-2648
pISSN - 0309-2402
DOI - 10.1111/jan.13692
Subject(s) - medicine , tuberculosis , chemoprophylaxis , referral , intervention (counseling) , psychological intervention , latent tuberculosis , prospective cohort study , pediatrics , family medicine , nursing , mycobacterium tuberculosis , pathology
Abstract Aim To evaluate the association of a new nursing intervention on the adherence to antituberculosis treatment in a paediatric cohort (<18 years). Background Tuberculosis remains a public health problem worldwide. The risk of developing tuberculosis after primary infection and its severity are higher in children. Proper adherence to antituberculosis treatment is critical for disease control. Design Nonrandomized controlled trial; Phase 1, retrospective (2011–2013), compared with Phase 2, prospective with intervention (2015–2016), in a referral centre for paediatric tuberculosis in Spain ( NCT 03230409). Methods A total of 359 patients who received antituberculosis drugs after close contact with a smear‐positive patient (primary chemoprophylaxis) or were treated for latent tuberculosis infection or tuberculosis disease were included, 261 in Phase 1 and 98 in Phase 2. In Phase 2, a new nurse‐led intervention was implemented in all patients and included two educational steps (written information in the child's native language and follow‐up telephone calls) and two monitoring steps (Eidus–Hamilton test and follow‐up questionnaire) that were exclusively carried out by nurses. Results Adherence to antituberculosis treatment increased from 74.7% in Phase 1% to 87.8% in Phase 2 ( p = 0.014; Chi‐square test), after the implementation of the nurse‐led intervention. In Phase 2, nonadherence was only associated with being born abroad (28.6% vs. 7.8%; p = 0.019; Chi‐square test) and with foreign origin families (27.3% vs. 0%; p < 0.0001; Chi‐square test). Conclusion The nurse‐led intervention was associated to an increase in adherence to antituberculosis treatment. Immigrant‐related variables remained major risk factors for sub‐optimal adherence in a low‐endemic setting.